Microdosing TRT The Future of Testosterone Replacement Therapy

The testosterone molecule can only become bioavailable when enzymes from the liver break down the carbon chains releasing the testosterone. In building muscle mass cycles, Testosterone E is usually combined with Deca Durabolin, Boldenone, Methandrostenolone, Anadrol, and/or Trenbolone. In muscle definition cycles, it is very successfully combined with Trenbolone, Winstrol, Masteron, and/or Primobolan. Testo Depot may be used with equal effect in both muscle growth and muscle definition cycles, the only difference being the dose.

On the contrary, we have also experienced positive results with patients using Testosterone Undecanoate, the difference being that we use a more frequent microdose to achieve stability.
This article will explore the causes of low testosterone levels, testosterone replacement therapy options, how testosterone injections work and the time they need to start working.
There is considerable variation in the half-life of unbound testosterone, ranging from 10 to 100 minutes.
This series has been a long time coming as my time gets limited and other interests drive my focus elsewhere but TRT is still one of the things I most enjoy doing.
The current UK reference range of nmol/l is very non-specific, doctors do not take age into consideration despite knowing there is an age-related decline in testosterone.

It is essential to differentiate between testosterone replacement therapy (TRT) and illegal anabolic steroids. Extensive research has shown that TRT has various health benefits for men provided by a physician who carefully monitors the dose, increasing it by small amounts if necessary. Depending on the brand, some testosterone injections can be self-administered or given by a family member or friend. Aveed is administered via deep intramuscular injection, which a medical practitioner must do. • Weight Lifting and Exercise — Research has shown that resistance training, such as weight lifting and high-intensity interval training (HIIT), can naturally boost testosterone levels.

Can I use other medicines with Sustanon 250 injections?

Another patient, a 37-year-old male, also joined our clinic during our initial TRT evolution. He too was commenced on Testosterone Undecanoate, however due to his age, he was also started on 500iu HCG every 3.5 days to help preserve fertility. Again, with an initial saturation dose of 1000mg Testosterone Undecanoate, followed by a six-week loading dose at 1000mg and then a follow up dose at 12 weeks. His injection interval was then adjusted according to his qualitative symptoms and trough readings. He now has optimal male androgen levels – Total Testosterone 28.2nmol/l and Oestradiol 97pmol/l – all other biomarkers are healthy and he feels a subjective improvement in his overall sense of well-being. A graph will follow once we’ve gathered enough data points to demonstrate this.

Side effects from the use of TESTO DEPO are certainly possible, but quite easy to prevent.
Nebido (Testosterone Undeconate) was the UK licenced drug for the treatment of Testosterone Deficiency Syndrome.
Hopefully, private practice is more than simply a fast-track service to treatment and a nice cup of coffee on arrival at a plush clinic!
Their model was far more progressive, they were not only managing total testosterone, they were also monitoring and managing high oestradiol and dihydrotestosterone.
Results from testosterone injections can vary, and it’s important to have realistic expectations.
This leads to significantly longer periods of low Testosterone; this will more than likely increase the risk of polycythaemia and cause a roller coaster of emotions.

We will now give you a brief background into pharmacokinetics, prior to demonstrating what the everyday environment can look like on different treatment protocols. Be under no illusion that this is a guide on “How To Prescribe TRT”, there are numerous complexities to achieving and sustaining hormonal balance that must be taken into consideration and regularly reviewed. These include physiological parameters, body composition, personal requirements and so on. Your TRT protocol must ALWAYS be under the supervision and guidance of a doctor specialising in TRT.

Testosterone Replacement Therapy (TRT) vs Anabolic Steroids

But this will subsequently decline soon thereafter, and further administrations of the drug are necessary to reach sufficient steady states. You must first understand that the total testosterone level is not a true marker by which qualitative and quantitive symptoms can be gauged. Total testosterone is not bioavailable, it is simply the precursor to the bioavailable androgens, free testosterone, oestradiol and dihydrotestosterone.

It has a high volume of distribution, this information helps you calculate the dose needed to achieve a critical plasma concentration. As already mentioned, there is individual variation in drug metabolism of the different esters and there is no defined optimal testosterone level, so you cannot apply a standard fixed dose and frequency of injection https://www.voicemith.com/uk-steroidsbuy-online-com/groundbreaking-study-reveals-remarkable-results-of/ to achieve stability. Therefore, to titrate your optimal dose and frequency, it is sensible to use only one variable. It also makes sense that the action of this variable should be predictable, something that has been demonstrated with testosterone enanthate; oestradiol and DHT levels exhibit saturable increases with increased dose(9).

Testosterone Enantate 250mg

After a suboptimal trough reading of 13.6nmol/l in September 2016, eight months after starting TRT, we made the decision to switch him to a 10-weekly injection interval. In December 2016, we also made the decision to introduce 500iu of HCG every 3.5 days because, despite shortening his injection interval and him noting a minor improvement in his sense of well-being on TRT, he still felt flat. Disappointingly, Patient Zero’s trough levels remained suboptimal so in January 2017, we moved him to shorter eight-week injection intervals.

Furthermore, as one can clearly see, 100mg would cause potentially supraphysiological levels on average, as 50mg elicits as high as 680ng/dL, or 23.6 nmol/L. Application within 12 hours would then cause another subsequent peak that gradually increases levels. Ideally, one would use a lower or mid dose cream and apply twice per day until stable levels are met. This is not to discredit the cream, as it works for some males and it can indeed mimic natural diurnal Testosterone release well too. Gold standard TRT extends even further than this, the aim is to also optimise function by giving men an appropriate dose of Testosterone and HCG for their genetics, physiological requirements, and subsequent utilisation.

Key facts about Sustanon (testosterone) injections

Not only do we need to adopt a personalised approach to patient-centred care, we need to appreciate the need for a holistic approach to medicine. TRT will not reverse the negative symptoms that the patient is experiencing if we do not support them in other aspects of their life. Hormones are not aware of what day of the week it is, or how far away you are from your next Testosterone dose, they follow a strict 24-hour circadian pattern, which is discussed in further detail in ‘The Endocrine System & Sleep’. Our gold standard TRT is daily subcutaneous Testosterone Cypionate (or Enanthate) and Human Chorionic Gonadotropin (HCG) injections. Natural testosterone levels fall slowly with age and fall rapidly following surgical removal of the testicles (for example in the treatment of testicular cancer). Levels may also fall due to testicular disease (hypogonadism or eunuchoidism), or disease of the pituitary gland (a gland in the brain that controls hormone production).

He had subsequent issues with elevated oestradiol and so Anastrozole (an aromatase inhibitor) was commenced to manage this. Disappointingly, after 15 months on Testosterone Undecanoate, alongside 300iu of HCG and 0.5mg of Anastrozole every 3.5 days, his trough level was still only 15.1nmol/l. Testosterone is lipid soluble which means it can permeate cell membranes to enter the cell to exert its effects.

Testo Depot – Omega Meds’ Testosterone Enanthate – 10 ampules 250mg

NHS protocols are safe, but they tend not to allow for prescribing outside of the guidelines. This simply means that the medicine is being used in a way that is different to that described in the product licence, which is agreed by the Medicines Healthcare Regulatory Authority (MHRA). It is even possible to prescribe medications for an intended purpose when there is no product license, such as Transscrotal Testosterone Cream, but this must be done with extreme caution. ‘Primum non nocere.’ In the private medical sector, practices vary widely, from doctor-led clinics to online providers, generally trending towards increased frequency protocols to help achieve more stable pharmacological levels.